Disease Detectives B/C

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Re: Disease Detectives B/C

Postby Alex-RCHS » March 20th, 2017, 1:55 pm

Reviving: What are the three things that characterize an agent's potential to spread and cause disease?
answer
virulence, infectivity, pathogenicity?
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Re: Disease Detectives B/C

Postby UTF-8 U+6211 U+662F » March 21st, 2017, 12:16 pm

answer
virulence, infectivity, pathogenicity?
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Re: Disease Detectives B/C

Postby Alex-RCHS » March 21st, 2017, 2:52 pm

Sorry if this is long... I got carried away.

General questions
1. Distribution is defined as the _________ and ____________ of the disease. (fill in the blanks)
2. Define surveillance.
3. The epidemiological triangle is made up of what 3 (or 4) things?
4. Define latency period.

Outbreak investigation
5. Drake hosted a party in celebration of the launch of "More Life." 314 people at the party ate from the buffet, which contained food contaminated with a pathogen. In total, 159 people who attended the party were infected with the pathogen. Of those, 2 died as a result of the disease. Many of those infected experienced an onset of vomiting within 6 hours of exposure. Many also experienced watery diarrhea and abdominal cramps between 5 and 35 hours after exposure.
a. What is the case fatality rate for this outbreak?
b. Based on the symptoms, name one pathogen that might have caused this outbreak.
c. If 89 people at the party did not eat from the buffet, and 7 of them were infected with the pathogen, calculate the relative risk of infection associated with eating from the buffet.
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Re: Disease Detectives B/C

Postby Unome » March 21st, 2017, 6:03 pm

Haven't looked at Disease since MIT so...
1. uh... location and concentration? 2. The scientific recording of cases in order to locate abnormalities in distribution (or more specific functions, like to monitor eradication programs) 3. host, vector, agent, and something else I don't remember 4. The time during which a pathogen does not cause active disease. This may or may not be the same as the incubation period, depending on the disease. 5. a. 2/159 = 0.0126 or 1.26% b. Cholera (yay microbes knowledge!) c. Number of people who were exposed and did not contract the disease: 159 - 7 = 152. Number of people who were exposed = 314. Number of people unexposed - 89. Number of people unexposed and infected = 7. Relative risk = ( 152 / 314 ) / ( 7 / 89 ) = 6.15
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Re: Disease Detectives B/C

Postby maxxxxx » March 21st, 2017, 6:09 pm

Sorry if this is long... I got carried away.

General questions
1. Distribution is defined as the _________ and ____________ of the disease. (fill in the blanks)
2. Define surveillance.
3. The epidemiological triangle is made up of what 3 (or 4) things?
4. Define latency period.

Outbreak investigation
5. Drake hosted a party in celebration of the launch of "More Life." 314 people at the party ate from the buffet, which contained food contaminated with a pathogen. In total, 159 people who attended the party were infected with the pathogen. Of those, 2 died as a result of the disease. Many of those infected experienced an onset of vomiting within 6 hours of exposure. Many also experienced watery diarrhea and abdominal cramps between 5 and 35 hours after exposure.
a. What is the case fatality rate for this outbreak?
b. Based on the symptoms, name one pathogen that might have caused this outbreak.
c. If 89 people at the party did not eat from the buffet, and 7 of them were infected with the pathogen, calculate the relative risk of infection associated with eating from the buffet.
I'll give this a shot
1. Frequency and Pattern 2. The systematic collection, analysis, interpretation, and dissemination of health data on an ongoing basis 3. Agent, Host, Environment 4. A period between exposure and onset of symptoms 5. a. 2/159 = 1.26% b. Bacillus cereus c. (159/225)/(7/89) = 8.98
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Re: Disease Detectives B/C

Postby yang573 » March 21st, 2017, 6:09 pm

Sorry if this is long... I got carried away.

General questions
1. Distribution is defined as the _________ and ____________ of the disease. (fill in the blanks)
2. Define surveillance.
3. The epidemiological triangle is made up of what 3 (or 4) things?
4. Define latency period.

Outbreak investigation
5. Drake hosted a party in celebration of the launch of "More Life." 314 people at the party ate from the buffet, which contained food contaminated with a pathogen. In total, 159 people who attended the party were infected with the pathogen. Of those, 2 died as a result of the disease. Many of those infected experienced an onset of vomiting within 6 hours of exposure. Many also experienced watery diarrhea and abdominal cramps between 5 and 35 hours after exposure.
a. What is the case fatality rate for this outbreak?
b. Based on the symptoms, name one pathogen that might have caused this outbreak.
c. If 89 people at the party did not eat from the buffet, and 7 of them were infected with the pathogen, calculate the relative risk of infection associated with eating from the buffet.
Here we go
1. [u]geographic extent[/u] and [u]prevalence[/u] 2. Surveillance is the systematic collection and analysis of public health data to monitor public health. 3. agent, host, & environment 4. latency period can mean 1. the period between exposure and onset of symptoms or 2. the period after exposure when the host is yet infectious 5. a. 2 deaths / 159 cases = 0.013 deaths/case = 1.3 deaths/100 cases b. Salmonella c . ill not ill exp. 159 155 not exp. 7 81 RR = (159/314) / (7/89) = 6.44
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Re: Disease Detectives B/C

Postby yang573 » March 21st, 2017, 6:18 pm

Whoops. I should have checked first. Give this one to Unome.
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Re: Disease Detectives B/C

Postby Alex-RCHS » March 21st, 2017, 6:45 pm

Unome answered first, and mostly correctly, so I'll give this to him.

Since the three answers given were sometimes conflicting, here are
the answers that I was thinking of
1. Frequency and pattern. 2. All of the given definitions seem good. 3. Host, agent, environment are the 3 main components, vector is often included. 4. I originally assumed that latency period was the same as incubation, but upon googling I've found different answers, so I'm not sure about that one. :oops: 5. a. 1.26% b. Cholera, B. Cereus, Salmonella, and a few others are all good answers. c. 6.15. This is how I did it, but Unome's way is better: Risk associated with eating from the buffet: (159-7)/314 = .4841 Risk associated with not eating from the buffet: 7/89 = .07865 Relative risk = .4841/.07865 = 6.15
(but I could be wrong on some)

Did nobody realize that the numbers I gave in the outbreak question were the first 14 digits of pi? :cry: 3.1415926535897...

Your turn, Unome.
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Re: Disease Detectives B/C

Postby Unome » March 23rd, 2017, 5:00 am

Question
For each of the three major types of epi curves, give one characteristic of its histogram, and one characteristic of the outbreak itself that could cause that type of curve.
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Re: Disease Detectives B/C

Postby yang573 » March 23rd, 2017, 5:33 am

Question
For each of the three major types of epi curves, give one characteristic of its histogram, and one characteristic of the outbreak itself that could cause that type of curve.
Answer
Common Source: A single, one-time exposure results in a single peak. Food-borne illness from a convention is one example. Continuous: A constant exposure results in a plateau of cases. The 1854 London Cholera outbreak is one example. Propagated: A host serves as a source of exposure for other susceptible hosts, resulting in a serious of growing peaks. A flu pandemic in which no one is initially immune would be one example.
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Re: Disease Detectives B/C

Postby Unome » March 23rd, 2017, 6:35 am

Question
For each of the three major types of epi curves, give one characteristic of its histogram, and one characteristic of the outbreak itself that could cause that type of curve.
Answer
Common Source: A single, one-time exposure results in a single peak. Food-borne illness from a convention is one example. Continuous: A constant exposure results in a plateau of cases. The 1854 London Cholera outbreak is one example. Propagated: A host serves as a source of exposure for other susceptible hosts, resulting in a serious of growing peaks. A flu pandemic in which no one is initially immune would be one example.
Correct, your turn.
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Re: Disease Detectives B/C

Postby yang573 » March 25th, 2017, 10:53 am

A bit late
A Minnesota health department enrolled 3,000 (healthy) individuals for 5 years to estimate the incidence rate of Hepatitis C in the Twin Cities metropolitan area. These people were called up annually, and the results are as follow: After the 1st year, 2 individuals had a new diagnosis for hepatitis C, and 78 were lost to follow up After the 2nd year, 0 individuals had been newly diagnosed with hepatitis C, and 90 were lost to follow up. After the 3rd year, 5 individuals had been newly diagnosed with hepatitis C, and 155 were lost to follow up. After the 4th year, 3 individuals had been newly diagnosed with hepatitis C, and 117 were lost to follow up. After the 5th year, 6 individuals had been newly diagnosed with hepatitis C, and 49 were lost to follow up. Calculate the incidence rate (in 1,000 person-years). Assume those lost to follow-up were disease-free for only half of the year.
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Re: Disease Detectives B/C

Postby Unome » March 27th, 2017, 7:44 am

A bit late
A Minnesota health department enrolled 3,000 (healthy) individuals for 5 years to estimate the incidence rate of Hepatitis C in the Twin Cities metropolitan area. These people were called up annually, and the results are as follow: After the 1st year, 2 individuals had a new diagnosis for hepatitis C, and 78 were lost to follow up After the 2nd year, 0 individuals had been newly diagnosed with hepatitis C, and 90 were lost to follow up. After the 3rd year, 5 individuals had been newly diagnosed with hepatitis C, and 155 were lost to follow up. After the 4th year, 3 individuals had been newly diagnosed with hepatitis C, and 117 were lost to follow up. After the 5th year, 6 individuals had been newly diagnosed with hepatitis C, and 49 were lost to follow up. Calculate the incidence rate (in 1,000 person-years). Assume those lost to follow-up were disease-free for only half of the year.
Time for me to start studying for this event again...
Assuming I'm just suppose to halve the number lost to follow up and add it on: 0.0521
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Re: Disease Detectives B/C

Postby yang573 » March 27th, 2017, 6:55 pm

Time for me to start studying for this event again...
Assuming I'm just suppose to halve the number lost to follow up and add it on: 0.0521
Hm, may I see your work? I got a different answer of 1.17 cases per 1,000 person-years. This is the source I used: https://www.cdc.gov/ophss/csels/dsepd/s ... tion2.html
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Re: Disease Detectives B/C

Postby Alex-RCHS » March 27th, 2017, 8:41 pm

Time for me to start studying for this event again...
Assuming I'm just suppose to halve the number lost to follow up and add it on: 0.0521
Hm, may I see your work? I got a different answer of 1.17 cases per 1,000 person-years. This is the source I used: https://www.cdc.gov/ophss/csels/dsepd/s ... tion2.html
I also got that answer. I added it up and ended up doing:
answer
16 new cases in 13710 person-years for an incidence of 1.167 cases per 1000 person-years.
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