Designer Genes C

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Designer Genes C

Post by pikachu4919 » July 15th, 2018, 3:08 pm

Designer Genes C: Participants will solve problems and analyze data or diagrams using their knowledge of the basic principles of genetics, molecular genetics and biotechnology.

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Re: Designer Genes C

Post by nicholasmaurer » September 11th, 2018, 12:37 pm

Does anyone care to offer an opinion on the distinction between "molecular consequences of mutations" (regional/state topic) and "mutations" (national-only topic)? I am very unclear on the distinction they intend to make. It would seem to me that it is near impossible to discussion the consequences of mutations without understanding the mutations themselves... Does this mean it's unfair to ask the definition of a point mutation, but perfectly acceptable to ask about the consequences of a point mutation?
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Re: Designer Genes C

Post by Unome » September 11th, 2018, 3:57 pm

nicholasmaurer wrote:Does anyone care to offer an opinion on the distinction between "molecular consequences of mutations" (regional/state topic) and "mutations" (national-only topic)? I am very unclear on the distinction they intend to make. It would seem to me that it is near impossible to discussion the consequences of mutations without understanding the mutations themselves... Does this mean it's unfair to ask the definition of a point mutation, but perfectly acceptable to ask about the consequences of a point mutation?
I suspect the national topic of mutations is a simplification of the more specific point mutations topic that existed in Heredity in the past ("Analysis of karyotypes for addition, substitution, translocation" or something to that effect, which was frequently used in practice to mean basically anything related to point mutations) that was brought over without comparison to the DG-exclusive topics. In practice, I'm thinking mutations are going to end up being used outside of nationals frequently.
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Re: Designer Genes C

Post by izzanom » September 14th, 2018, 4:46 pm

Can anyone explain how to find additions and deletions on karyotypes?

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Re: Designer Genes C

Post by pikachu4919 » September 15th, 2018, 11:21 pm

izzanom wrote:Can anyone explain how to find additions and deletions on karyotypes?
A karyotype is a diagram that shows the chromosomes within the nuclei of a cell. From there, combine that with knowledge of how many chromosomes a normal version of the organism has, and then if any are missing or if there are extra or if some are longer or shorter, then you can deduce additions/deletions from there.
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Re: Designer Genes C

Post by daycd » September 19th, 2018, 9:06 pm

nicholasmaurer wrote:Does anyone care to offer an opinion on the distinction between "molecular consequences of mutations" (regional/state topic) and "mutations" (national-only topic)?
I would think that consequences of a mutation relate to function. So you could think in terms of loss and gain (No protein or more protein; no RNA or more RNA). Obviously different types of mutation can lead to similar changes in function. For example, a deletion, an insertion or a point mutation could lead to complete loss of function.

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Re: Designer Genes C

Post by nicholasmaurer » September 20th, 2018, 4:39 am

daycd wrote:
nicholasmaurer wrote:Does anyone care to offer an opinion on the distinction between "molecular consequences of mutations" (regional/state topic) and "mutations" (national-only topic)?
I would think that consequences of a mutation relate to function. So you could think in terms of loss and gain (No protein or more protein; no RNA or more RNA). Obviously different types of mutation can lead to similar changes in function. For example, a deletion, an insertion or a point mutation could lead to complete loss of function.
Correct. But its unclear to me whether asking a question such as "Is a nonsense mutation more likely to lead to a gain-of-function or loss-of-function mutation?" would be legal. For some reason, they seem to have put the consequences of mutations in scope, and the types of mutations out of scope, which seems reversed to me...
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Re: Designer Genes C

Post by jaspattack » September 21st, 2018, 1:35 pm

Molecular consequences of mutations likely refers to specifically the consequences, and mutations likely includes the types and causes of mutations (while still covering the consequences). The rules for Heredity also mention mutations as a national topic. Still feels a little odd that the types and causes aren't as important, but I'm not the one who wrote the rules.
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Re: Designer Genes C

Post by nicholasmaurer » September 21st, 2018, 2:08 pm

jaspattack wrote:Molecular consequences of mutations likely refers to specifically the consequences, and mutations likely includes the types and causes of mutations (while still covering the consequences). The rules for Heredity also mention mutations as a national topic. Still feels a little odd that the types and causes aren't as important, but I'm not the one who wrote the rules.
Yes, but how are you supposed to discuss the consequences of mutations without discussing the mutations themselves?
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Re: Designer Genes C

Post by pikachu4919 » September 23rd, 2018, 9:23 am

nicholasmaurer wrote:
jaspattack wrote:Molecular consequences of mutations likely refers to specifically the consequences, and mutations likely includes the types and causes of mutations (while still covering the consequences). The rules for Heredity also mention mutations as a national topic. Still feels a little odd that the types and causes aren't as important, but I'm not the one who wrote the rules.
Yes, but how are you supposed to discuss the consequences of mutations without discussing the mutations themselves?
True, it's like trying to explain the effect that Klinefelter's Syndrome has on someone's body yet not including in that explanation that Klinefelter's is caused by a nondisjunction mutation in which cells that normally have an X and a Y chromosome additionally have an extra X chromosome, even though that is THE reason for the symptoms of the condition.
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