Designer Genes C

[pikachu4919]

Designer Genes C: Participants will solve problems and analyze data or diagrams using their knowledge of the basic principles of genetics, molecular genetics and biotechnology.

Designer Genes Wiki

Designer Genes Test Exchange 2014

Past Threads: 2013, 2014

Past Question Marathons: 2014

[nicholasmaurer]

Does anyone care to offer an opinion on the distinction between "molecular consequences of mutations" (regional/state topic) and "mutations" (national-only topic)? I am very unclear on the distinction they intend to make. It would seem to me that it is near impossible to discussion the consequences of mutations without understanding the mutations themselves... Does this mean it's unfair to ask the definition of a point mutation, but perfectly acceptable to ask about the consequences of a point mutation?

[Unome]

Does anyone care to offer an opinion on the distinction between "molecular consequences of mutations" (regional/state topic) and "mutations" (national-only topic)? I am very unclear on the distinction they intend to make. It would seem to me that it is near impossible to discussion the consequences of mutations without understanding the mutations themselves... Does this mean it's unfair to ask the definition of a point mutation, but perfectly acceptable to ask about the consequences of a point mutation?

I suspect the national topic of mutations is a simplification of the more specific point mutations topic that existed in Heredity in the past ("Analysis of karyotypes for addition, substitution, translocation" or something to that effect, which was frequently used in practice to mean basically anything related to point mutations) that was brought over without comparison to the DG-exclusive topics. In practice, I'm thinking mutations are going to end up being used outside of nationals frequently.

[izzanom]

Can anyone explain how to find additions and deletions on karyotypes?

[pikachu4919]

Can anyone explain how to find additions and deletions on karyotypes?

A karyotype is a diagram that shows the chromosomes within the nuclei of a cell. From there, combine that with knowledge of how many chromosomes a normal version of the organism has, and then if any are missing or if there are extra or if some are longer or shorter, then you can deduce additions/deletions from there.

[daycd]

Does anyone care to offer an opinion on the distinction between "molecular consequences of mutations" (regional/state topic) and "mutations" (national-only topic)?

I would think that consequences of a mutation relate to function. So you could think in terms of loss and gain (No protein or more protein; no RNA or more RNA). Obviously different types of mutation can lead to similar changes in function. For example, a deletion, an insertion or a point mutation could lead to complete loss of function.

[nicholasmaurer]

Does anyone care to offer an opinion on the distinction between "molecular consequences of mutations" (regional/state topic) and "mutations" (national-only topic)?

I would think that consequences of a mutation relate to function. So you could think in terms of loss and gain (No protein or more protein; no RNA or more RNA). Obviously different types of mutation can lead to similar changes in function. For example, a deletion, an insertion or a point mutation could lead to complete loss of function.

Correct. But its unclear to me whether asking a question such as "Is a nonsense mutation more likely to lead to a gain-of-function or loss-of-function mutation?" would be legal. For some reason, they seem to have put the consequences of mutations in scope, and the types of mutations out of scope, which seems reversed to me...

[jaspattack]

Molecular consequences of mutations likely refers to specifically the consequences, and mutations likely includes the types and causes of mutations (while still covering the consequences). The rules for Heredity also mention mutations as a national topic. Still feels a little odd that the types and causes aren't as important, but I'm not the one who wrote the rules.

[nicholasmaurer]

Molecular consequences of mutations likely refers to specifically the consequences, and mutations likely includes the types and causes of mutations (while still covering the consequences). The rules for Heredity also mention mutations as a national topic. Still feels a little odd that the types and causes aren't as important, but I'm not the one who wrote the rules.

Yes, but how are you supposed to discuss the consequences of mutations without discussing the mutations themselves?

[pikachu4919]

Molecular consequences of mutations likely refers to specifically the consequences, and mutations likely includes the types and causes of mutations (while still covering the consequences). The rules for Heredity also mention mutations as a national topic. Still feels a little odd that the types and causes aren't as important, but I'm not the one who wrote the rules.

Yes, but how are you supposed to discuss the consequences of mutations without discussing the mutations themselves?

True, it's like trying to explain the effect that Klinefelter's Syndrome has on someone's body yet not including in that explanation that Klinefelter's is caused by a nondisjunction mutation in which cells that normally have an X and a Y chromosome additionally have an extra X chromosome, even though that is THE reason for the symptoms of the condition.

[venules]

On a similar note, for "human karyotype analysis for nondisjunction disorders", would that focus solely on identification/consequences or would it also broach the causes?

[pikachu4919]

On a similar note, for "human karyotype analysis for nondisjunction disorders", would that focus solely on identification/consequences or would it also broach the causes?

Again, we don't know exactly what the rules committee intended with the way they wrote those rules, unless rules clarifications get submitted/answered/posted or unless someone from the life sciences committee cares to pop up on the forums and explain. In my personal opinion I think there's a good chance that people who write tests for Designer Genes will probably cover the mutations themselves because those are literally THE REASON why they exist, but again, *shrugs*

Disclaimer: the above is my opinion and may not necessarily reflect the true intention of the committee overlords.

[Unome]

I stand by my speculative opinion that the reason for the discrepancy on mutations is because after the Heredity rules were reworked, their contents were transferred into DG without much looking into how the specific wording of the two fit together. I believe the transfer didn't happen until after SOSI.

[nicholasmaurer]

On a similar note, for "human karyotype analysis for nondisjunction disorders", would that focus solely on identification/consequences or would it also broach the causes?

Again, we don't know exactly what the rules committee intended with the way they wrote those rules, unless rules clarifications get submitted/answered/posted or unless someone from the life sciences committee cares to pop up on the forums and explain. In my personal opinion I think there's a good chance that people who write tests for Designer Genes will probably cover the mutations themselves because those are literally THE REASON why they exist, but again, *shrugs*

Disclaimer: the above is my opinion and may not necessarily reflect the true intention of the committee overlords.

They have posted as response to my FAQ. Mutation types are in-scope, as expected.

[sheinbergd19]

Should I devote space on my note sheet to a codon chart, or will that information most likely be provided?