WangwithaTang wrote: ↑
February 19th, 2020, 10:54 pm
If yellow bone marrow can convert to red bone marrow, can red bone marrow convert back to yellow bone marrow? If not, why not? And how does this mechanism work anyway?
At birth, all bone marrow is hematopoietic. This is due to the body's need to produce blood cells at an early age. The maintenance of this hematopoietic tissue requires the support of hematopoietic microenvironment cells—fibroblasts, reticular adventitial cells, and macrophages—specialized mesenchymal cells in the bone marrow cavity.
These microenvironment cells are generally thought of in a three-step pathway:
1.) Support hematopoiesis; contain no adipose tissue (red bone marrow).
2.) Cannot support steady hematopoiesis; contain accumulated adipose tissue. When the body requires more blood cells to be produced—whether due to blood loss, fever, etc.—these cells literally just lose their fat, which allows them to support hematopoiesis again. This effectively reverts them back to the first stage. When the need for increased hematopoiesis declines, these cells continue "maturing."
3.) Cannot support hematopoiesis altogether; primarily contain adipose tissue (yellow bone marrow).