Anyone wanna help out a SciOly newcomer with protein modeling? This is the first year our school has a strong program, and we have a lot of oppurtunity, so I really want to know how to do well.
What is the focus area for the written portion of this competition? And how can my team make our models a lot better than just the generic model with no add-ons?
First, I recommend that you read the Protein Modeling Wiki
. It's incomplete, but it will be continually updated with more information.
Second, the written portion of the competition will involve general protein structure, composition, and function questions, and specifically for this year it will also focus on induced pluripotent stem cells
. (There's not very much about those on the wiki yet, but Wikipedia has some information.)
Third, for good add-ons, you should do some research on the protein you're modeling (Klf4) and figure out what its function is– and what parts of it are specifically involved in that function. You should highlight those parts, particularly any specific sidechains that interact with whatever it acts upon.
If you have any more specific questions, we would be happy to answer in greater detail.