Due to continuing complications and precautions around the coronavirus outbreak, the qualifying Regional tournaments for the 2021 Ohio State Tournament were virtual and the normal 8 Regions were combined into two "super-regions". The Western Region (Region 2) hosted Regions 3 (Eastern Region), 6 (Central Ohio Region), and 8 (Northeastern Region); while the Northeastern Region (Region 1) hosted the other 4 regions at the Northeastern Virtual Combined Regional. The tournament was held virtually on scilympiad on March 13th, 2021. Due to its larger size 26 Division B schools and 25 Division C schools qualified for the State Tournament. Many schools did not field teams this season.
- 1 Since schools that bring two teams can only advance one of them, and since there were two teams registered that did not participate all remaining teams (25) advanced to the State Tournament.
- 1 Ties were broken by the most gold place medals- Hudson High School's Blue team had four 1st place medals while Centerville High School's Black team had six.
Complete results for both Divisions are on the scoresheet and were also released by on video