The Penn Science Olympiad Invitational is a Division C invitational hosted in Philadelphia, Pennsylvania, by Science Olympiad at the University of Pennsylvania (SOUP). It is entirely student-run, and was first hosted on February 18th in 2017.
|Date||February 22nd, 2020|
|Year||Champion||Runner-up||Third Place||Fourth Place||Fifth Place||Teams|
|2017||Mason High School (89)||Harriton High School B (187)||Harriton High School A (189)||Fayetteville-Manlius High School (194)||West Windsor-Plainsboro High School South (203)||42|
|2018||Liberal Arts and Science Academy (162)||New Trier High School A (224)||Columbia High School (229)||Harriton High School B (235)||Harriton High School A (242)||50|
|2019||Troy High School A (120)||Mason High School A (173)||West Windsor-Plainsboro High School North B (219)||New Trier High School A (245)||Lower Merion High School B (252)||47|