Difference between revisions of "Anatomy/Digestive Secretion List"
Jump to navigation
Jump to search
m (oops I am bad at formatting) |
(Added to and consolidated digestive enzymes) |
||
Line 56: | Line 56: | ||
|Regulates pH of duodenal contents; increases watery bicarbonate solution from pancreatic & bile duct epithelium; triggers increased release from pancreas following oral glucose intake; inhibits gastrin release from stomach from G cells; stimulates pepsin secretion from chief cells & release of glucagon, pancreatic polypeptide, somatostatin | |Regulates pH of duodenal contents; increases watery bicarbonate solution from pancreatic & bile duct epithelium; triggers increased release from pancreas following oral glucose intake; inhibits gastrin release from stomach from G cells; stimulates pepsin secretion from chief cells & release of glucagon, pancreatic polypeptide, somatostatin | ||
|Used in medical field, esp. in pancreatic function tests (increases pancreatic secretions); first hormone identified | |Used in medical field, esp. in pancreatic function tests (increases pancreatic secretions); first hormone identified | ||
+ | |- | ||
+ | |} | ||
+ | |||
+ | {|class="wikitable" | ||
+ | |+Digestive Enzymes | ||
+ | !Enzyme Name | ||
+ | !Source | ||
+ | !Substrates | ||
+ | !Products | ||
+ | !Notes (if applicable) | ||
+ | |- | ||
+ | !Aminopeptidase | ||
+ | |Small intestine | ||
+ | |Amino acid at amino end of peptides | ||
+ | |Amino acids & peptides | ||
+ | |n/a | ||
+ | |- | ||
+ | !Carboxypeptidase | ||
+ | |Pancreatic acinar cells | ||
+ | |Amino acid at carboxyl end of peptides | ||
+ | |Amino acids & peptides | ||
+ | |Activated from procarboxypeptidase by trypsin; optimum pH varies | ||
+ | |- | ||
+ | !Chymotrypsin | ||
+ | |Pancreatic acinar cells | ||
+ | |Proteins | ||
+ | |Peptides | ||
+ | |Activated from chymotrypsinogen by trypsin; optimum pH 7.8 | ||
+ | |- | ||
+ | !Deoxyribonuclease | ||
+ | |Pancreatic acinar cells | ||
+ | |DNA | ||
+ | |Nucleotides | ||
+ | |n/a | ||
+ | |- | ||
+ | !Dipeptidase | ||
+ | |Small intestine | ||
+ | |Dipeptides | ||
+ | |Amino acids | ||
+ | |n/a | ||
+ | |- | ||
+ | !Elastase | ||
+ | |Pancreatic acinar cells | ||
+ | |Proteins | ||
+ | |Peptides | ||
+ | |Activated from proelastase by trypsin | ||
+ | |- | ||
+ | !Enterokinase | ||
+ | |Small intestine | ||
+ | |Trypsinogen | ||
+ | |Trypsin | ||
+ | |n/a | ||
+ | |- | ||
+ | !Gastric lipase | ||
+ | |Stomach chief cells | ||
+ | |Triglycerides | ||
+ | |Fatty acids & monoglycerides | ||
+ | |Optimum pH 4-5 | ||
+ | |- | ||
+ | !Lactase | ||
+ | |Small intestine | ||
+ | |Lactose | ||
+ | |Glucose & galactose | ||
+ | |n/a | ||
+ | |- | ||
+ | !Lingual lipase | ||
+ | |Lingual glands in tongue | ||
+ | |Triglycerides (fats & oils) & other lipids | ||
+ | |Fatty acids & diglycerides | ||
+ | |Optimum pH 4.5-5.5 | ||
+ | |- | ||
+ | !Maltase | ||
+ | |Small intestine | ||
+ | |Maltose | ||
+ | |Glucose | ||
+ | |n/a | ||
+ | |- | ||
+ | !Nucleosidases & phosphatases | ||
+ | |Small intestine | ||
+ | |Nucleotides | ||
+ | |Nitrogenous bases, pentoses, phosphates | ||
+ | |n/a | ||
+ | |- | ||
+ | !Pancreatic amylase | ||
+ | |Pancreatic acinar cells | ||
+ | |Starches | ||
+ | |Maltose, maltotriose, α-dextrins | ||
+ | |Optimum pH 6.7-7.0 | ||
+ | |- | ||
+ | !Pancreatic lipase | ||
+ | |Pancreatic acinar cells | ||
+ | |Triglycerides emulsified by bile salts | ||
+ | |Fatty acids & monoglycerides | ||
+ | |Optimum pH 8.0 | ||
+ | |- | ||
+ | !Pepsin | ||
+ | |Stomach chief cells | ||
+ | |Proteins | ||
+ | |Peptides | ||
+ | |Activated from pepsinogen by pepsin & HCl; optimum pH 1.5-1.6 | ||
+ | |- | ||
+ | !Ribonuclease | ||
+ | |Pancreatic acinar cells | ||
+ | |RNA | ||
+ | |Nucleotides | ||
+ | |n/a | ||
+ | |- | ||
+ | !Sucrase | ||
+ | |Small intestine | ||
+ | |Sucrose | ||
+ | |Glucose & fructose | ||
+ | |n/a | ||
+ | |- | ||
+ | !Salivary amylase | ||
+ | |Salivary glands | ||
+ | |Starches | ||
+ | |Maltose, maltotriose (trisaccharide), α-dextrins | ||
+ | |Optimum pH 6.7-7 | ||
+ | |- | ||
+ | !Trypsin | ||
+ | |Pancreatic acinar cells | ||
+ | |Proteins | ||
+ | |Peptides | ||
+ | |Activated from trypsinogen by enterokinase; optimum pH 7.8-8.7 | ||
+ | |- | ||
+ | !α-Dextrinase | ||
+ | |Small intestine | ||
+ | |α-dextrins | ||
+ | |Glucose | ||
+ | |n/a | ||
|- | |- | ||
|} | |} | ||
Line 64: | Line 194: | ||
|- | |- | ||
|Saliva||Moistens, Lubricates||6.5-7.5 | |Saliva||Moistens, Lubricates||6.5-7.5 | ||
− | |||
− | |||
− | |||
− | |||
|- | |- | ||
|<span style="color:#E00000">Lysozyme</span>||Kills Bacteria||--- | |<span style="color:#E00000">Lysozyme</span>||Kills Bacteria||--- | ||
Line 86: | Line 212: | ||
|+Stomach- Chief Cells | |+Stomach- Chief Cells | ||
!Fluid/Enzyme!!Function!!Optimum pH | !Fluid/Enzyme!!Function!!Optimum pH | ||
− | |||
− | |||
− | |||
− | |||
|- | |- | ||
|<span style="color:#E00000">Chymosin</span>||Coagulates Milk||3.5 | |<span style="color:#E00000">Chymosin</span>||Coagulates Milk||3.5 | ||
Line 122: | Line 244: | ||
|Bicarbonate Ions||controls pH levels||alkaline | |Bicarbonate Ions||controls pH levels||alkaline | ||
|- | |- | ||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
|} | |} | ||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
− | |||
[[Category:Anatomy]] | [[Category:Anatomy]] |
Revision as of 07:29, 24 March 2012
For the Digestive System page, see Anatomy/Digestive System
Various parts of the digestive tract secrete many enzymes and fluids. This page is a comprehensive list of those secretions, their source, and their functions.
- Enzymes speed up digestive processes to make digestion faster.
- Hormones can stimulate digestion, and the release of hormones into the organs.
- Mucus can protect the inner wall of organs, as well as lubricating them for movement.
Digestive Secretion List
Hormone Name | Produced By | Secreted By | Method of Stimulation | Effect | Notes (if applicable) |
---|---|---|---|---|---|
Cholecystokinin (CCK) | L-cells in the mucosal epithelium of the small intestine | Duodenum | Fatty acids and peptides | Causes release of digestive enzymes and bile from the pancreas and gallbladder, respectively; slightly decreases gastric secretion; causes contraction of the gallbladder & relaxation of the hepatopancreatic ampullar sphincter; strongly decreases gastric motility; hunger suppressant | Induces drug tolerance to opioids and is implicated in the pain hypersensitivity during opioid withdrawal; peptide |
Gastric Inhibitory Peptide (GIP) | K cells, found in the mucosa of the duodenum and jejunum | K cells, found in the mucosa of the duodenum and jejunum | n/a | Induces insulin secretion; has significant effect on fatty acid metabolism | Does NOT neutralize stomach acid (that's secretin); absence of GIP receptors correlated with resistance to obesity |
Gastrin | G cells in the antrum of the stomach, duodenum, and pancreas | G cells of the duodenum and in the pyloric antrum of the stomach | Distension; partially digested proteins, autonomic stimulation, ingestion of alcohol or caffeine – release inhibited by stomach pH of 2 (negative feedback) & somatostatin, secretin, gastroinhibitory peptide, vasoactive intestinal peptide, glucagon, calcitonin | Stimulates secretion of gastric acid (HCl) by the parietal cells in the stomach; causes a minor increase in gastric motility; stimulates parietal cell maturation & fundal growth; induces pancreatic secretions & gallbladder emptying | Peptide; found primarily in big (34), little (17), & mini (14) forms, with numbers referring to amino acid count. Optimum pH 5-7 |
Motilin | M cells in the small intestine, esp. duodenum & jejunum | M cells in the small intestine, esp. duodenum & jejunum | Alkaline pH in the duodenum | Increases the migrating myoelectric complex component of GI motility; stimulates the production of pepsin; increases release of pancreatic polypeptide & somatostatin; "housekeeper of the gut" – improves peristalsis in the small intestine & clears the gut to prepare for the next meal | n/a |
Secretin (SCT) | Cytoplasmic secretory granules of S-cells, in the mucosa of the duodenum & (in smaller numbers) the jejunum | Duodenum | Low duodenal pH (2-4.5) – release inhibited by H2 antagonists | Regulates pH of duodenal contents; increases watery bicarbonate solution from pancreatic & bile duct epithelium; triggers increased release from pancreas following oral glucose intake; inhibits gastrin release from stomach from G cells; stimulates pepsin secretion from chief cells & release of glucagon, pancreatic polypeptide, somatostatin | Used in medical field, esp. in pancreatic function tests (increases pancreatic secretions); first hormone identified |
Enzyme Name | Source | Substrates | Products | Notes (if applicable) |
---|---|---|---|---|
Aminopeptidase | Small intestine | Amino acid at amino end of peptides | Amino acids & peptides | n/a |
Carboxypeptidase | Pancreatic acinar cells | Amino acid at carboxyl end of peptides | Amino acids & peptides | Activated from procarboxypeptidase by trypsin; optimum pH varies |
Chymotrypsin | Pancreatic acinar cells | Proteins | Peptides | Activated from chymotrypsinogen by trypsin; optimum pH 7.8 |
Deoxyribonuclease | Pancreatic acinar cells | DNA | Nucleotides | n/a |
Dipeptidase | Small intestine | Dipeptides | Amino acids | n/a |
Elastase | Pancreatic acinar cells | Proteins | Peptides | Activated from proelastase by trypsin |
Enterokinase | Small intestine | Trypsinogen | Trypsin | n/a |
Gastric lipase | Stomach chief cells | Triglycerides | Fatty acids & monoglycerides | Optimum pH 4-5 |
Lactase | Small intestine | Lactose | Glucose & galactose | n/a |
Lingual lipase | Lingual glands in tongue | Triglycerides (fats & oils) & other lipids | Fatty acids & diglycerides | Optimum pH 4.5-5.5 |
Maltase | Small intestine | Maltose | Glucose | n/a |
Nucleosidases & phosphatases | Small intestine | Nucleotides | Nitrogenous bases, pentoses, phosphates | n/a |
Pancreatic amylase | Pancreatic acinar cells | Starches | Maltose, maltotriose, α-dextrins | Optimum pH 6.7-7.0 |
Pancreatic lipase | Pancreatic acinar cells | Triglycerides emulsified by bile salts | Fatty acids & monoglycerides | Optimum pH 8.0 |
Pepsin | Stomach chief cells | Proteins | Peptides | Activated from pepsinogen by pepsin & HCl; optimum pH 1.5-1.6 |
Ribonuclease | Pancreatic acinar cells | RNA | Nucleotides | n/a |
Sucrase | Small intestine | Sucrose | Glucose & fructose | n/a |
Salivary amylase | Salivary glands | Starches | Maltose, maltotriose (trisaccharide), α-dextrins | Optimum pH 6.7-7 |
Trypsin | Pancreatic acinar cells | Proteins | Peptides | Activated from trypsinogen by enterokinase; optimum pH 7.8-8.7 |
α-Dextrinase | Small intestine | α-dextrins | Glucose | n/a |
Fluid/Enzyme | Function | Optimum pH |
---|---|---|
Saliva | Moistens, Lubricates | 6.5-7.5 |
Lysozyme | Kills Bacteria | --- |
Fluid/Enzyme | Function | Optimum pH |
---|---|---|
Mucus | Protects Stomach Wall | --- |
Fluid/Enzyme | Function | Optimum pH |
---|---|---|
Chymosin | Coagulates Milk | 3.5 |
Fluid/Enzyme | Function | Optimum pH |
---|---|---|
Hydrochloric Acid | Kills Bacteria, Activates Pepsinogen -> Pepsin, Lowers pH level | 1 |
Inrinsic Factor | Absorbs Vitamin B12 | 7 |
Fluid/Enzyme | Function | Optimum pH |
---|---|---|
Bile | Assists in the digestion of lipids | 7.5-8.8 |
Fluid/Enzyme | Function | Optimum pH |
---|---|---|
Bicarbonate Ions | controls pH levels | alkaline |